GABAA receptor
GABAB receptor

GABAA receptor 選擇性激活劑 | 激動劑 | 拮抗劑 | 化學(xué)產(chǎn)品

目錄號	產(chǎn)品名	產(chǎn)品描述	Selective / Pan	IC50 / Ki
S1989	GABAA receptor agent 1	GABAA receptor agent 1 is a high affinity ligand for Gamma-aminobutyric acid A (GABAA) receptor that exerts potent anticonvulsant activity.	Selective
S4494	Methionine	Methionine (MRX-1024, D-Methionine) is an activitor of GABAA receptor that modulates neuronal activity.	Selective
S3663	Afloqualone	Afloqualone (AFQ, HQ-495) is a quinazolinone family GABAergic drug with muscle-relaxant and sedative effects, showing the agonist activity at the β subtype of the GABAa receptor.	Selective
S3634	6-Hydroxyflavone (6-HF)	6-Hydroxyflavone, a naturally occurring flavonoid, binds to GABAA receptors with moderate affinity and acts as a partial agonist of GABAA receptors.	Selective
S5049	Thiocolchicoside	Thiocolchicoside (Thiocolchicine 2-glucoside analog, Coltramyl) is a natural occuring glycoside originated from the flower seeds of superba gloriosa with anti-inflammatory and analgesic properties as well as pronounced convulsant activity. It is also an antagonist of GABAA receptor.	Selective
S7071	(+)-Bicuculline	(+)-Bicuculline (d-Bicuculline) is a competitive antagonist of GABA_A receptors with IC50 of 2 μM, also blocks Ca(2+)-activated potassium channels.	Selective	GABAA receptor, IC50: 2 μM
S3786	Glabridin	Glabridin (Q-100692, KB-289522, LS-176045), one of the active phytochemicals in licorice extract, binds to and activates the ligand binding domain of PPARγ, as well as the full length receptor. It is also a GABAA receptor positive modulator promoting fatty acid oxidation and improving learning and memory.	Selective	α1β2γ2 (GABAA receptor), EC50: 6.3 μM; α1β3γ2 (GABAA receptor), EC50: 6.83 μM; α1β2 (GABAA receptor), EC50: 9.63 μM; α1β1γ2 (GABAA receptor), EC50: 17.23 μM
S5194	Furosemide sodium	Furosemide (Frusemide) sodium is a potent and orally active inhibitor of Na-K-Cl cotransporter (NKCC). Furosemide sodium is a subtype-selective antagonist of gamma-aminobutyric acid type A (GABAA) receptor.	Selective
S2399	Dihydromyricetin	Dihydromyricetin (Ampelopsin, Ampeloptin) is a natural antioxidant flavonoid from Ampelopsis grossedentata.	Selective
S4197	Bemegride	Bemegride(Bemegrid,3-Ethyl-3-methylglutarimide) is a central nervous system stimulant and antidote for barbiturate poisoning.	Selective
S1332	Flumazenil (RO 15-1788)	Flumazenil (RO 15-1788) is a competitive GABAA receptor antagonist, used in the treatment of benzodiazepine overdoses.	Selective